{"id":5071,"date":"2021-02-12T11:39:22","date_gmt":"2021-02-12T19:39:22","guid":{"rendered":"https:\/\/stagewp.westernu.edu\/osteopathic\/?page_id=5071"},"modified":"2024-03-08T09:44:11","modified_gmt":"2024-03-08T17:44:11","slug":"elsalanty-lab","status":"publish","type":"page","link":"https:\/\/stagewp.westernu.edu\/osteopathic\/research\/labs\/elsalanty-lab\/","title":{"rendered":"Elsalanty Lab"},"content":{"rendered":"<section class=\"hero-secondary\">\n  <div class=\"relative bg-black\">\n                <img decoding=\"async\" class=\"adhere object-cover\" src=\"\/media\/osteopathic\/elsalanty-research.jpg\" srcset=\"\" sizes=\"100vw\" alt=\"elsalanty research - composite of 6 images\">\n      <div class=\"adhere gradient-overlay\"><\/div>\n        <div class=\"relative container pt-56 md:pt-112 pb-144 md:pb-192\">\n      <div class=\"md:flex md:justify-between px-12\">\n        <div class=\"sm:w-8\/12 md:w-6\/12 xl:w-5\/12 px-12\">\n                      <div class=\"mb-20\">\n              <div class=\"block font-sans font-bold text-14 text-white leading-130\">\n  <span class=\"inline-block\">\n    <a href=\"\/\" class=\"block hover:underline\">WesternU<\/a>\n  <\/span>\n      <span class=\"inline-block mx-6\">\/<\/span>\n          <a href=\"https:\/\/stagewp.westernu.edu\/osteopathic\" class=\"inline-block hover:underline\">College of Osteopathic Medicine of the Pacific (COMP) and COMP-Northwest<\/a>\n          <span class=\"inline-block mx-6\">\/<\/span>\n      <a href=\"https:\/\/stagewp.westernu.edu\/osteopathic\/research\/\" class=\"inline-block hover:underline\">Research<\/a>\n    <span class=\"inline-block mx-6\">\/<\/span>\n      <a href=\"https:\/\/stagewp.westernu.edu\/osteopathic\/research\/labs\/\" class=\"inline-block hover:underline\">Research Labs<\/a>\n    <span class=\"inline-block mx-6\">\/<\/span>\n    <span class=\"inline-block\">COMP (CA): Elsalanty Lab<\/span>\n  <\/div>            <\/div>\n                                        <h1 class=\"t-h1-sans  text-white\">COMP (CA): Elsalanty Lab<\/h1>\n        <\/div>\n              <\/div>\n    <\/div>\n  <\/div>\n<\/section>\n\n\n<section class=\"relative my-48 md:my-72\">\n  <div class=\"container\">\n    <div class=\"lg:flex px-12 lg:justify-start\">\n              <div class=\"w-full lg:w-5\/12 2xl:w-4\/12 -mt-80 md:-mt-112 mb-48 px-12 lg:pr-32\">\n                              <nav class=\"py-28 px-40 2xl:px-64 rounded-5 md:rounded-8 bg-gray-darker text-white mb-40\">\n            <ul>\n                                              <li class=\"block my-8\">\n                  <a class=\"text-22 font-normal leading-130 tracking-20 text-white hover:text-yellow transition-default\" href=\"https:\/\/stagewp.westernu.edu\/osteopathic\/research\/labs\/\" target=\"_self\" rel=\"noopener\">Research Labs<\/a>\n                <\/li>\n                                              <li class=\"block my-8\">\n                  <a class=\"text-22 font-normal leading-130 tracking-20 text-white hover:text-yellow transition-default\" href=\"https:\/\/stagewp.westernu.edu\/osteopathic\/research\/labs\/bi-lab\/\" target=\"_self\" rel=\"noopener\">Bi Lab<\/a>\n                <\/li>\n                                              <li class=\"block my-8\">\n                  <a class=\"text-22 font-normal leading-130 tracking-20 text-white hover:text-yellow transition-default\" href=\"https:\/\/stagewp.westernu.edu\/osteopathic\/research\/labs\/elsalanty-lab\/\" target=\"_self\" rel=\"noopener\">Elsalanty Lab<\/a>\n                <\/li>\n                                              <li class=\"block my-8\">\n                  <a class=\"text-22 font-normal leading-130 tracking-20 text-white hover:text-yellow transition-default\" href=\"https:\/\/stagewp.westernu.edu\/osteopathic\/research\/labs\/fricano-lab\/\" target=\"_self\" rel=\"noopener\">Fricano Lab<\/a>\n                <\/li>\n                                              <li class=\"block my-8\">\n                  <a class=\"text-22 font-normal leading-130 tracking-20 text-white hover:text-yellow transition-default\" href=\"https:\/\/stagewp.westernu.edu\/osteopathic\/research\/labs\/nalley-lab\/\" target=\"_self\" rel=\"noopener\">Nalley Lab<\/a>\n                <\/li>\n                                              <li class=\"block my-8\">\n                  <a class=\"text-22 font-normal leading-130 tracking-20 text-white hover:text-yellow transition-default\" href=\"https:\/\/stagewp.westernu.edu\/osteopathic\/research\/labs\/peterfy-lab\/\" target=\"_self\" rel=\"noopener\">Peterfy Lab<\/a>\n                <\/li>\n                                              <li class=\"block my-8\">\n                  <a class=\"text-22 font-normal leading-130 tracking-20 text-white hover:text-yellow transition-default\" href=\"https:\/\/stagewp.westernu.edu\/osteopathic\/research\/labs\/scott-lab\/\" target=\"_self\" rel=\"noopener\">Scott Lab<\/a>\n                <\/li>\n                                              <li class=\"block my-8\">\n                  <a class=\"text-22 font-normal leading-130 tracking-20 text-white hover:text-yellow transition-default\" href=\"https:\/\/stagewp.westernu.edu\/osteopathic\/research\/labs\/sperling-lab\/\" target=\"_self\" rel=\"noopener\">Sperling Lab<\/a>\n                <\/li>\n                                              <li class=\"block my-8\">\n                  <a class=\"text-22 font-normal leading-130 tracking-20 text-white hover:text-yellow transition-default\" href=\"https:\/\/stagewp.westernu.edu\/osteopathic\/research\/labs\/steinauer-lab\/\" target=\"_self\" rel=\"noopener\">Steinauer Lab<\/a>\n                <\/li>\n                                              <li class=\"block my-8\">\n                  <a class=\"text-22 font-normal leading-130 tracking-20 text-white hover:text-yellow transition-default\" href=\"https:\/\/stagewp.westernu.edu\/osteopathic\/research\/labs\/szurmant-lab\/\" target=\"_self\" rel=\"noopener\">Szurmant Lab<\/a>\n                <\/li>\n                                              <li class=\"block my-8\">\n                  <a class=\"text-22 font-normal leading-130 tracking-20 text-white hover:text-yellow transition-default\" href=\"https:\/\/stagewp.westernu.edu\/osteopathic\/research\/labs\/venketaraman-lab\/\" target=\"_self\" rel=\"noopener\">Venketaraman Lab<\/a>\n                <\/li>\n                                              <li class=\"block my-8\">\n                  <a class=\"text-22 font-normal leading-130 tracking-20 text-white hover:text-yellow transition-default\" href=\"https:\/\/stagewp.westernu.edu\/osteopathic\/research\/labs\/wagner\/\" target=\"_self\" rel=\"noopener\">Wagner Lab<\/a>\n                <\/li>\n                                              <li class=\"block my-8\">\n                  <a class=\"text-22 font-normal leading-130 tracking-20 text-white hover:text-yellow transition-default\" href=\"https:\/\/stagewp.westernu.edu\/osteopathic\/research\/labs\/wedel-lab\/\" target=\"_self\" rel=\"noopener\">Wedel Lab<\/a>\n                <\/li>\n                          <\/ul>\n          <\/nav>\n                            <\/div>\n      \n      \n                  \n                  \n      <div class=\"w-full px-24 wysiwyg-content lg:w-7\/12 2xl:w-7\/12\">\n        <p>The oral cavity is one of the unique microenvironments in the body. The interactions between alveolar bone, dental tissues, oral mucosa, oral bacteria, immune cells, and saliva define several physiological and pathological processes that are specific to the oral cavity. Alveolar bone shows unique patterns of adaptation to mechanical loading, disuse, aging, and remodeling-altering medications, especially bisphosphonates.<\/p>\n<h2><\/h2>\n<p>&nbsp;<\/p>\n\n      <\/div>\n    <\/div>\n  <\/div>\n<\/section>\n\n\n\n\n\n\n\n<section class=\"relative my-48 md:my-72\" vue-app>\n  <div class=\"container\">\n        <app-accordion class=\"px-24 lg:w-4\/5 mx-auto\">\n              <app-accordion-item class=\"accordion-group block leading-1 opt-1\" content-class=\"accordion-group__panel wysiwyg-content\">\n          <template #accordion-trigger=\"{ href, visible, setRef, clickHandler }\">\n            <a :href=\"'#' + href\" \n              :ref=\"setRef\"\n              :class=\"['accordion-group__button scroll-mt-160', {'accordion__trigger_active': visible}]\"\n              @click.stop.prevent=\"clickHandler\"\n            >\n            <span class=\"block py-10\">\n              Research Areas\n            <\/span>\n            <span class=\"accordion-group-icon relative flex w-56 h-56 ml-20 justify-center items-center bg-black rounded-full flex-shrink-0\">\n                            <span class=\"w-16 icon-chevron-down\">\n                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><!--!Font Awesome Free 6.6.0 by @fontawesome - https:\/\/fontawesome.com License - https:\/\/fontawesome.com\/license\/free Copyright 2024 Fonticons, Inc.--><path d=\"M233.4 406.6c12.5 12.5 32.8 12.5 45.3 0l192-192c12.5-12.5 12.5-32.8 0-45.3s-32.8-12.5-45.3 0L256 338.7 86.6 169.4c-12.5-12.5-32.8-12.5-45.3 0s-12.5 32.8 0 45.3l192 192z\"\/><\/svg>\n              <\/span>\n              <span class=\"w-16 icon-chevron-up\">\n                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><!--!Font Awesome Free 6.6.0 by @fontawesome - https:\/\/fontawesome.com License - https:\/\/fontawesome.com\/license\/free Copyright 2024 Fonticons, Inc.--><path d=\"M233.4 105.4c12.5-12.5 32.8-12.5 45.3 0l192 192c12.5 12.5 12.5 32.8 0 45.3s-32.8 12.5-45.3 0L256 173.3 86.6 342.6c-12.5 12.5-32.8 12.5-45.3 0s-12.5-32.8 0-45.3l192-192z\"\/><\/svg>\n              <\/span>\n                          <\/span>\n            <\/a>\n          <\/template>\n          <template #accordion-content>\n            <p>&nbsp;<\/p>\n<h2>Dr. Elsalanty\u2019s lab has been investigating the interaction between alveolar bone and the soft tissues during regeneration and mechanical loading.<\/h2>\n<p><img decoding=\"async\" class=\"aligncenter wp-image-5073\" title=\"My Document Name\" src=\"\/media\/osteopathic\/elsalanty-research.jpg\" alt=\"\" width=\"800\" height=\"450\" \/><\/p>\n<p><b>Zol impaired DCs\u2019 activity in vivo leading to increased bacterial load in MRONJ rat model:<\/b><\/p>\n<p>Rats were treated with 80ug\/kg Zol for 13 weeks (n=13 per group), oral swabs were taken for analysis of bacterial content followed by extractions of 1<sup>st<\/sup>\u00a0and 2<sup>nd<\/sup>\u00a0mandibular molars and isolation of cervical lymph nodes 2 weeks post extraction (n= 3 per group) and harvest of mandibles (n=10 per group) and gingival tissues (n=5 per group) 8 weeks after extraction.\u00a0<b>A<\/b>: Universal 16SrRNA qPCR showing difference in bacterial content on oral mucosa of Zol and control animals; gene expression of the 16srRNA was assessed with the CT values and graph plotted as I\/CT on the y-axis.\u00a0<b>B:<\/b>\u00a0Representative clinical pictures of extraction sites (8 weeks post extraction) of Zol and control animals.\u00a0<b>C<\/b>: IHC labeling of DCs in gingival tissues using anti CD11c and anti MHCII in consecutive sections (2.5x photomicrograph of the gingival tissue was taken to show the area of analysis in lamina propria as indicated by white box, which was further magnified at 40x) and quantified using ImageJ software as shown with<b>\u00a0<\/b>bar graphs<b>\u00a0<\/b>in<b>\u00a0D<\/b>.<b>\u00a0E:\u00a0<\/b>IHC labeling of DCs in cervical lymph nodes using anti CD11c and anti MHCII in consecutive sections, (2.5x photomicrograph of the lymph node was taken to show the area of analysis in paracortex as indicated by white box, which was further magnified at 40x) and quantified using ImageJ software as shown bar graphs in\u00a0<b>\u00a0F.\u00a0\u00a0<\/b>(* p&lt;0.05, ** p&lt;0.01, *** p&lt;0.001)<\/p>\n<hr \/>\n<p>Recently, his team has focused on exploring the mechanisms for medication-associated osteonecrosis of the jaw (ONJ), as a venue to explore the mechanisms that make the condition exclusive to jawbones, as well as developing strategies for preventing such a serious condition.\u00a0<strong style=\"font-style: inherit;\">They are currently exploring the unique response of alveolar bone to anti-resorptive medications from three interconnected directions<\/strong>.\u00a0<strong style=\"font-style: inherit;\">The first<\/strong>\u00a0is to investigate the role of matrix-bound bisphosphonates in the pathogenesis of bisphosphonate-related osteonecrosis of the jaw (BRONJ).\u00a0<strong style=\"font-style: inherit;\">The hypothesis<\/strong>\u00a0is that bisphosphonate molecules that become embedded into the bone matrix remain accessible and biologically active and they affect bone homeostasis through the impairment of osteoclast and osteocyte functions.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>The second direction<\/strong>\u00a0is to investigate the effects of bisphosphonates on osteoclast-mediated angiogenesis in alveolar bone. Strong preliminary data support the hypothesis that bisphosphonates impair post-extraction angiogenesis in the jaw. We are currently investigating the effect of bisphosphonates on PDGF-BB pathway in pre-osteoclasts, and whether this pathway plays a role in post-extraction angiogenesis.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>The third direction<\/strong>\u00a0is to study the effect of matrix-bound bisphosphonates on biofilm formation and localized immune response in the jaw. Preliminary data shows that bisphosphonate-treated animals have higher bacterial content in the oral cavity under baseline conditions. The long-term goal is to uncover mechanisms by which alveolar bone reacts to pathological conditions and aging-related changes and develop strategies to extend the health-span of musculoskeletal tissues.<\/p>\n<p>&nbsp;<\/p>\n\n          <\/template>\n        <\/app-accordion-item>\n              <app-accordion-item class=\"accordion-group block leading-1 opt-1\" content-class=\"accordion-group__panel wysiwyg-content\">\n          <template #accordion-trigger=\"{ href, visible, setRef, clickHandler }\">\n            <a :href=\"'#' + href\" \n              :ref=\"setRef\"\n              :class=\"['accordion-group__button scroll-mt-160', {'accordion__trigger_active': visible}]\"\n              @click.stop.prevent=\"clickHandler\"\n            >\n            <span class=\"block py-10\">\n              Publications\n            <\/span>\n            <span class=\"accordion-group-icon relative flex w-56 h-56 ml-20 justify-center items-center bg-black rounded-full flex-shrink-0\">\n                            <span class=\"w-16 icon-chevron-down\">\n                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><!--!Font Awesome Free 6.6.0 by @fontawesome - https:\/\/fontawesome.com License - https:\/\/fontawesome.com\/license\/free Copyright 2024 Fonticons, Inc.--><path d=\"M233.4 406.6c12.5 12.5 32.8 12.5 45.3 0l192-192c12.5-12.5 12.5-32.8 0-45.3s-32.8-12.5-45.3 0L256 338.7 86.6 169.4c-12.5-12.5-32.8-12.5-45.3 0s-12.5 32.8 0 45.3l192 192z\"\/><\/svg>\n              <\/span>\n              <span class=\"w-16 icon-chevron-up\">\n                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><!--!Font Awesome Free 6.6.0 by @fontawesome - https:\/\/fontawesome.com License - https:\/\/fontawesome.com\/license\/free Copyright 2024 Fonticons, Inc.--><path d=\"M233.4 105.4c12.5-12.5 32.8-12.5 45.3 0l192 192c12.5 12.5 12.5 32.8 0 45.3s-32.8 12.5-45.3 0L256 173.3 86.6 342.6c-12.5 12.5-32.8 12.5-45.3 0s-12.5-32.8 0-45.3l192-192z\"\/><\/svg>\n              <\/span>\n                          <\/span>\n            <\/a>\n          <\/template>\n          <template #accordion-content>\n            <p><strong>Selected Publications<\/strong><\/p>\n<p>Elsayed R, Kurago Z, Cutler CW, Arce RM, Gerber J, Celis E, Sultan H, Elashiry M, Meghil M, Sun C, Auersvald CM, Awad ME, Zeitoun R, Elsayed R, Eldin M Elshikh M, Isales C,\u00a0<strong>Elsalanty ME<\/strong>. Role of dendritic cell-mediated immune response in oral homeostasis: A new mechanism of osteonecrosis of the jaw. FASEB J. 2020 Feb;34(2):2595-2608. doi: 10.1096\/fj.201901819RR. Epub 2020 Jan 9. PMID: 31919918<\/p>\n<p>Awad ME, Sun C, Jernigan J,\u00a0<strong>Elsalanty M<\/strong>. Serum C-terminal cross-linking telopeptide level as a predictive biomarker of osteonecrosis after dentoalveolar surgery in patients receiving bisphosphonate therapy: Systematic review and meta-analysis. J Am Dent Assoc. 2019 Aug;150(8):664-675.e8. doi:10.1016\/j.adaj.2019.03.006. Epub 2019 Jun 28. PMID: 31256803; PMCID: PMC6839407.<\/p>\n<p>Salgueiro M, Stribos M, Zhang LF, Stevens M, Awad ME,\u00a0<strong>Elsalanty M<\/strong>. Value of pre-operative CTX serum levels in the prediction of medication-related osteonecrosis of the jaw (MRONJ): a retrospective clinical study. EPMA J. 2019 Jan 24;10(1):21-29. doi: 10.1007\/s13167-019-0160-3. eCollection 2019 Mar. PubMed PMID: 30984311; PubMed Central PMCID: PMC6459452<\/p>\n<p>Awad, ME; Altman, A; Elrefai,R; Shipman, P; Looney, S;\u00a0<strong>Elsalanty<\/strong>. The Use of Vascularized fibula flap in Mandibular reconstruction; A comprehensive systematic review and Meta-analysis of the observational studies.Journal of Craniomaxillofacial surgery.<\/p>\n<p>Elsayed R, Abraham P, Awad ME, Kurago Z, Baladhandayutham B, Whitford GM, Pashley DH, McKenna CE,<strong>Elsalanty<\/strong><strong>ME<\/strong>. Removal of matrix-bound zoledronate prevents post-extraction osteonecrosis of the jaw by rescuing osteoclast function. Bone. 2018 Feb 8;110:141-149. doi: 10.1016\/j.bone.2018.01.030. [Epub ahead of print] PMID:29408511<\/p>\n<p>Howie RN, Bhattacharyya M, Salama ME, Refaey ME, Isales C, Borke J, Daoudi A, Medani F,\u00a0<strong>Elsalanty ME<\/strong>. Removal of pamidronate from bone in rats using systemic and local chelation. Arch Oral Biol. 2015 Sep 7;60(12):1699-1707. doi: 10.1016\/j.archoralbio.2015.09.001. [Epub ahead of print] PMID: 26431826<\/p>\n<p>Howie RN, Borke JL, Kurago Z, Daoudi A, Cray J, Zakhary IE, Brown TL, Raley JN, Tran LT, Messer R, Medani F,\u00a0<strong>Elsalanty ME<\/strong>. A Model for Osteonecrosis of the Jaw with Zoledronate Treatment following Repeated Major Trauma. PLoS One. 2015 Jul 17;10(7):e0132520. doi: 10.1371\/journal.pone.0132520. eCollection 2015. PMID: 26186665<\/p>\n<p><strong>Book Chapter:\u00a0<\/strong>Elsalanty, ME. Bone Development and Histogenesis of the Jaw. In Tolstunov, L (Editor). Horizontal alveolar ridge augmentation in implant dentistry, 1st Edition, Wiley Blackwell, Inc. 2016<\/p>\n<p><strong><a href=\"https:\/\/www.mededportal.org\/publication\/9169\" target=\"_blank\" rel=\"noopener\">Educational Publication<\/a>:\u00a0<\/strong>Elsalanty M. Early Tooth Development. MedEdPORTAL; 2012.<\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Elsalanty&amp;sort=date\" target=\"_blank\" rel=\"noopener\"><strong>Full List of Publications<\/strong><\/a><\/p>\n\n          <\/template>\n        <\/app-accordion-item>\n          <\/app-accordion>\n  <\/div>\n<\/section>\n\n<section class=\"faculty-card my-48 md:my-72\">\n  <div class=\"container\">\n          <\/div>\n<\/section>\n\n\n<section class=\"faculty-card my-48 md:my-72\">\n  <div class=\"container\">\n        <div class=\"md:flex md:justify-between md:items-end mb-20\">\n      <h2 class=\"t-h2-sans  text-red md:mr-40\">MOHAMMED E. ELSALANTY, PhD<\/h2>\n    <\/div>\n            <div class=\"md:flex md:flex-wrap px-12\">\n                                                      \n                                                        \n      <div class=\"px-12 mt-24 w-full md:w-1\/2\">\n        <div class=\"sm:flex w-full py-32 border-b-1 border-gray\">\n                                            <a href=\"\/bios\/?bio=melsalanty\" class=\"card block w-256 sm:w-1\/3 pl-12 md:pl-0 pr-12 md:pr-18 mr-auto md:mr-0\">\n                <div class=\"rounded-5 md:rounded-8 overflow-hidden\">\n                    <img decoding=\"async\" class=\"card__image w-full h-256 sm:h-192 md:h-144 lg:h-192 xl:h-256 object-cover\" alt=\"Portrait of MOHAMMED E. ELSALANTY, PhD\" src=\"\/media\/westernu\/images\/staff\/melsalanty.jpg\" \/>\n                <\/div>\n            <\/a>\n                                <div class=\"w-full h-full md:w-2\/3 pl-12 md:pl-18 mt-18 sm:mt-0\">\n            <p class=\"t-h2-serif leading-120\">\n                            <a href=\"\/bios\/?bio=melsalanty\" class=\"text-red-light hover:text-red\">MOHAMMED E. ELSALANTY, PhD<\/a>\n                          <\/p>\n            <div class=\"mt-16 t-p2\">\n                            <p class=\"font-bold\">College of Osteopathic Medicine of the Pacific<\/p>\n                                          <p class=\"font-bold\">Professor and Chair of Anatomy<\/p>\n                                                                      <p>\n                <a href=\"mailto:melsalanty@westernu.edu\" class=\"hover:underline\">melsalanty@westernu.edu <\/a>\n              <\/p>\n                                        <\/div>\n          <\/div>\n        <\/div>\n      <\/div>\n          <\/div>\n      <\/div>\n<\/section>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":34,"featured_media":0,"parent":8215,"menu_order":8,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-5071","page","type-page","status-publish","hentry"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/stagewp.westernu.edu\/osteopathic\/wp-json\/wp\/v2\/pages\/5071","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/stagewp.westernu.edu\/osteopathic\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/stagewp.westernu.edu\/osteopathic\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/stagewp.westernu.edu\/osteopathic\/wp-json\/wp\/v2\/users\/34"}],"replies":[{"embeddable":true,"href":"https:\/\/stagewp.westernu.edu\/osteopathic\/wp-json\/wp\/v2\/comments?post=5071"}],"version-history":[{"count":20,"href":"https:\/\/stagewp.westernu.edu\/osteopathic\/wp-json\/wp\/v2\/pages\/5071\/revisions"}],"predecessor-version":[{"id":14732,"href":"https:\/\/stagewp.westernu.edu\/osteopathic\/wp-json\/wp\/v2\/pages\/5071\/revisions\/14732"}],"up":[{"embeddable":true,"href":"https:\/\/stagewp.westernu.edu\/osteopathic\/wp-json\/wp\/v2\/pages\/8215"}],"wp:attachment":[{"href":"https:\/\/stagewp.westernu.edu\/osteopathic\/wp-json\/wp\/v2\/media?parent=5071"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}