{"id":2956,"date":"2018-03-15T09:48:27","date_gmt":"2018-03-15T16:48:27","guid":{"rendered":"http:\/\/stagewp.westernu.edu\/osteopathic\/?page_id=2956"},"modified":"2024-04-16T10:30:26","modified_gmt":"2024-04-16T17:30:26","slug":"peterfy-lab","status":"publish","type":"page","link":"https:\/\/stagewp.westernu.edu\/osteopathic\/research\/labs\/peterfy-lab\/","title":{"rendered":"Peterfy Lab"},"content":{"rendered":"<section class=\"hero-secondary\">\n  <div class=\"relative bg-black\">\n                <img decoding=\"async\" class=\"adhere object-cover\" src=\"\/media\/osteopathic\/images\/research\/peterfy-and-his-team.jpg\" srcset=\"\" sizes=\"100vw\" alt=\"Peterfy and his research team\">\n      <div class=\"adhere gradient-overlay\"><\/div>\n        <div class=\"relative container pt-56 md:pt-112 pb-144 md:pb-192\">\n      <div class=\"md:flex md:justify-between px-12\">\n        <div class=\"sm:w-8\/12 md:w-6\/12 xl:w-5\/12 px-12\">\n                      <div class=\"mb-20\">\n              <div class=\"block font-sans font-bold text-14 text-white leading-130\">\n  <span class=\"inline-block\">\n    <a href=\"\/\" class=\"block hover:underline\">WesternU<\/a>\n  <\/span>\n      <span class=\"inline-block mx-6\">\/<\/span>\n          <a href=\"https:\/\/stagewp.westernu.edu\/osteopathic\" class=\"inline-block hover:underline\">College of Osteopathic Medicine of the Pacific (COMP) and COMP-Northwest<\/a>\n          <span class=\"inline-block mx-6\">\/<\/span>\n      <a href=\"https:\/\/stagewp.westernu.edu\/osteopathic\/research\/\" class=\"inline-block hover:underline\">Research<\/a>\n    <span class=\"inline-block mx-6\">\/<\/span>\n      <a href=\"https:\/\/stagewp.westernu.edu\/osteopathic\/research\/labs\/\" class=\"inline-block hover:underline\">Research Labs<\/a>\n    <span class=\"inline-block mx-6\">\/<\/span>\n    <span class=\"inline-block\">COMP (CA): Peterfy Lab<\/span>\n  <\/div>            <\/div>\n                                        <h1 class=\"t-h1-sans  text-white\">COMP (CA): Peterfy Lab<\/h1>\n        <\/div>\n              <\/div>\n    <\/div>\n  <\/div>\n<\/section>\n\n\n<section class=\"relative my-48 md:my-72\">\n  <div class=\"container\">\n    <div class=\"lg:flex px-12 lg:justify-start\">\n              <div class=\"w-full lg:w-5\/12 2xl:w-4\/12 -mt-80 md:-mt-112 mb-48 px-12 lg:pr-32\">\n                              <nav class=\"py-28 px-40 2xl:px-64 rounded-5 md:rounded-8 bg-gray-darker text-white mb-40\">\n            <ul>\n                                              <li class=\"block my-8\">\n                  <a class=\"text-22 font-normal leading-130 tracking-20 text-white hover:text-yellow transition-default\" href=\"https:\/\/stagewp.westernu.edu\/osteopathic\/research\/labs\/\" target=\"_self\" rel=\"noopener\">Research Labs<\/a>\n                <\/li>\n                                              <li class=\"block my-8\">\n                  <a class=\"text-22 font-normal leading-130 tracking-20 text-white hover:text-yellow transition-default\" href=\"https:\/\/stagewp.westernu.edu\/osteopathic\/research\/labs\/bi-lab\/\" target=\"_self\" rel=\"noopener\">Bi Lab<\/a>\n                <\/li>\n                                              <li class=\"block my-8\">\n                  <a class=\"text-22 font-normal leading-130 tracking-20 text-white hover:text-yellow transition-default\" href=\"https:\/\/stagewp.westernu.edu\/osteopathic\/research\/labs\/elsalanty-lab\/\" target=\"_self\" rel=\"noopener\">Elsalanty Lab<\/a>\n                <\/li>\n                                              <li class=\"block my-8\">\n                  <a class=\"text-22 font-normal leading-130 tracking-20 text-white hover:text-yellow transition-default\" href=\"https:\/\/stagewp.westernu.edu\/osteopathic\/research\/labs\/fricano-lab\/\" target=\"_self\" rel=\"noopener\">Fricano Lab<\/a>\n                <\/li>\n                                              <li class=\"block my-8\">\n                  <a class=\"text-22 font-normal leading-130 tracking-20 text-white hover:text-yellow transition-default\" href=\"https:\/\/stagewp.westernu.edu\/osteopathic\/research\/labs\/nalley-lab\/\" target=\"_self\" rel=\"noopener\">Nalley Lab<\/a>\n                <\/li>\n                                              <li class=\"block my-8\">\n                  <a class=\"text-22 font-normal leading-130 tracking-20 text-white hover:text-yellow transition-default\" href=\"https:\/\/stagewp.westernu.edu\/osteopathic\/research\/labs\/peterfy-lab\/\" target=\"_self\" rel=\"noopener\">Peterfy Lab<\/a>\n                <\/li>\n                                              <li class=\"block my-8\">\n                  <a class=\"text-22 font-normal leading-130 tracking-20 text-white hover:text-yellow transition-default\" href=\"https:\/\/stagewp.westernu.edu\/osteopathic\/research\/labs\/scott-lab\/\" target=\"_self\" rel=\"noopener\">Scott Lab<\/a>\n                <\/li>\n                                              <li class=\"block my-8\">\n                  <a class=\"text-22 font-normal leading-130 tracking-20 text-white hover:text-yellow transition-default\" href=\"https:\/\/stagewp.westernu.edu\/osteopathic\/research\/labs\/sperling-lab\/\" target=\"_self\" rel=\"noopener\">Sperling Lab<\/a>\n                <\/li>\n                                              <li class=\"block my-8\">\n                  <a class=\"text-22 font-normal leading-130 tracking-20 text-white hover:text-yellow transition-default\" href=\"https:\/\/stagewp.westernu.edu\/osteopathic\/research\/labs\/steinauer-lab\/\" target=\"_self\" rel=\"noopener\">Steinauer Lab<\/a>\n                <\/li>\n                                              <li class=\"block my-8\">\n                  <a class=\"text-22 font-normal leading-130 tracking-20 text-white hover:text-yellow transition-default\" href=\"https:\/\/stagewp.westernu.edu\/osteopathic\/research\/labs\/szurmant-lab\/\" target=\"_self\" rel=\"noopener\">Szurmant Lab<\/a>\n                <\/li>\n                                              <li class=\"block my-8\">\n                  <a class=\"text-22 font-normal leading-130 tracking-20 text-white hover:text-yellow transition-default\" href=\"https:\/\/stagewp.westernu.edu\/osteopathic\/research\/labs\/venketaraman-lab\/\" target=\"_self\" rel=\"noopener\">Venketaraman Lab<\/a>\n                <\/li>\n                                              <li class=\"block my-8\">\n                  <a class=\"text-22 font-normal leading-130 tracking-20 text-white hover:text-yellow transition-default\" href=\"https:\/\/stagewp.westernu.edu\/osteopathic\/research\/labs\/wagner\/\" target=\"_self\" rel=\"noopener\">Wagner Lab<\/a>\n                <\/li>\n                                              <li class=\"block my-8\">\n                  <a class=\"text-22 font-normal leading-130 tracking-20 text-white hover:text-yellow transition-default\" href=\"https:\/\/stagewp.westernu.edu\/osteopathic\/research\/labs\/wedel-lab\/\" target=\"_self\" rel=\"noopener\">Wedel Lab<\/a>\n                <\/li>\n                          <\/ul>\n          <\/nav>\n                            <\/div>\n      \n      \n                  \n                  \n      <div class=\"w-full px-24 wysiwyg-content lg:w-7\/12 2xl:w-7\/12\">\n        <h2>Genetic determinants of common metabolic diseases<\/h2>\n<p>Research in the Peterfy Laboratory focuses on common metabolic diseases including obesity, diabetes and dyslipidemia. Our goal is to identify novel genes and mechanisms responsible for metabolic abnormalities and provide the foundation for the development of novel therapeutic approaches. The Peterfy Laboratory is affiliated with the College of Osteopathic Medicine of the Pacific.<\/p>\n\n      <\/div>\n    <\/div>\n  <\/div>\n<\/section>\n\n\n\n\n\n\n\n<section class=\"relative my-48 md:my-72\" vue-app>\n  <div class=\"container\">\n        <app-accordion class=\"px-24 lg:w-4\/5 mx-auto\">\n              <app-accordion-item class=\"accordion-group block leading-1 opt-1\" content-class=\"accordion-group__panel wysiwyg-content\">\n          <template #accordion-trigger=\"{ href, visible, setRef, clickHandler }\">\n            <a :href=\"'#' + href\" \n              :ref=\"setRef\"\n              :class=\"['accordion-group__button scroll-mt-160', {'accordion__trigger_active': visible}]\"\n              @click.stop.prevent=\"clickHandler\"\n            >\n            <span class=\"block py-10\">\n              Research Areas\n            <\/span>\n            <span class=\"accordion-group-icon relative flex w-56 h-56 ml-20 justify-center items-center bg-black rounded-full flex-shrink-0\">\n                            <span class=\"w-16 icon-chevron-down\">\n                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><!--!Font Awesome Free 6.6.0 by @fontawesome - https:\/\/fontawesome.com License - https:\/\/fontawesome.com\/license\/free Copyright 2024 Fonticons, Inc.--><path d=\"M233.4 406.6c12.5 12.5 32.8 12.5 45.3 0l192-192c12.5-12.5 12.5-32.8 0-45.3s-32.8-12.5-45.3 0L256 338.7 86.6 169.4c-12.5-12.5-32.8-12.5-45.3 0s-12.5 32.8 0 45.3l192 192z\"\/><\/svg>\n              <\/span>\n              <span class=\"w-16 icon-chevron-up\">\n                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><!--!Font Awesome Free 6.6.0 by @fontawesome - https:\/\/fontawesome.com License - https:\/\/fontawesome.com\/license\/free Copyright 2024 Fonticons, Inc.--><path d=\"M233.4 105.4c12.5-12.5 32.8-12.5 45.3 0l192 192c12.5 12.5 12.5 32.8 0 45.3s-32.8 12.5-45.3 0L256 173.3 86.6 342.6c-12.5 12.5-32.8 12.5-45.3 0s-12.5-32.8 0-45.3l192-192z\"\/><\/svg>\n              <\/span>\n                          <\/span>\n            <\/a>\n          <\/template>\n          <template #accordion-content>\n            <p>The overall goal of the Peterfy Laboratory is to understand mechanisms involved in common metabolic conditions such as obesity, diabetes and dyslipidemia. Our research strategy is to identify genes associated with metabolic abnormalities in mouse models or humans, followed by mechanistic studies using molecular, cellular and organismal approaches. To identify genes of metabolic interest, we have been pursuing two general strategies. The first strategy exploits naturally occurring genetic variation in the mouse to discover genes responsible for metabolic phenotypes. In the second strategy, we identify candidate genes based on human genetic data, followed by characterization in engineered mouse models. Current projects in the Peterfy Laboratory focus on dyslipidemia (i.e., abnormal levels of cholesterol and triglycerides in the circulation), a principal risk factor for coronary artery disease and associated mortality. Our studies aim to identify molecular determinants and mechanisms responsible for dyslipidemia to enable the development of novel therapeutic approaches.<\/p>\n<h2>The Role of Lipase Maturation Factor (LMF1) in Plasma Lipid Metabolism<\/h2>\n<p>The LMF1 gene was discovered in a naturally occurring mutant mouse strain (cld, combined lipase deficient) exhibiting hyperlipidemia. LMF1 is a chaperone residing within the endoplasmic reticulum (ER), where it is required for the post-translational activation of several lipases involved in plasma lipid metabolism: lipoprotein lipase (LPL), hepatic lipase (HL) and endothelial lipase (EL). In the absence of functional LMF1, as in cld mutant mice, these lipases are inactive and triglyceride clearance is impaired, leading to the accumulation of lipids in the circulation. Similar to the cld mouse model, human LMF1 mutations are associated with lipase deficiency and hypertriglyceridemia.<\/p>\n<div class=\"one_half layout-column\">\n<p><strong>Our current studies on LMF1 aim to:<\/strong><\/p>\n<ul>\n<li>Understand the role of LMF1 in the modulation of lipases and plasma lipid levels through the characterization of tissue-specific knock-out mouse models.<\/li>\n<li>Identify molecular mechanisms regulating LMF1 function using biochemical and molecular biological techniques.<\/li>\n<li>Explore lipase-independent roles of LMF1 in ER homeostasis using cell biological approaches.<\/li>\n<\/ul>\n<\/div>\n<div class=\"one_half layout-column\"><img decoding=\"async\" class=\"alignleft size-full wp-image-2961\" title=\"\" src=\"\/media\/osteopathic\/images\/research\/Structure-and-function-of-LMF1.jpg\" alt=\"\" width=\"300\" height=\"285\" \/> <em>Structure and function of LMF1. Mouse and human mutations associated with hyperlipidemia are indicated with red dots.<\/em><\/div>\n<h2>Genetic determinants of plasma lipid variation in human populations<\/h2>\n<p>Genome-wide association studies (GWAS) in human populations have uncovered numerous chromosomal regions associated with a variety of metabolic traits, including plasma lipids such as cholesterol and triglycerides. Many of the lipid-associated chromosomal intervals contain genes not previously implicated in lipid metabolism and offer a rich resource for the identification of novel genes and mechanisms affecting this process. Thus, the overall goal of our project is to use human GWAS data as the starting point to discover novel determinants of plasma lipid levels.<\/p>\n<p><strong>Major aims of the project are to:<\/strong><\/p>\n<ul>\n<li>Functionally validate candidate genes in lipid-associated genomic intervals using in vivo overexpression and knock-down approaches in mouse models.<\/li>\n<li>Identify molecular mechanisms by which lipid-associated genes affect plasma lipid levels using in vitro and in vivo approaches.<\/li>\n<li>Identify causative genomic variants through the functional analysis of lipid-associated haplotypes.<\/li>\n<li><img decoding=\"async\" class=\"alignleft size-full wp-image-2962\" title=\"\" src=\"\/media\/osteopathic\/images\/research\/lipid-associated-chromosomal-intervals.jpg\" alt=\"\" width=\"600\" height=\"265\" \/><\/li>\n<\/ul>\n<p><em>Functional analysis of lipid-associated chromosomal intervals. The functional genomic variant is labeled by red asteri<\/em><em>sk. )<\/em><\/p>\n<p>&nbsp;<\/p>\n<h2>Funding National Institutes of Health (NHLBI)<\/h2>\n<p>&nbsp;<\/p>\n\n          <\/template>\n        <\/app-accordion-item>\n              <app-accordion-item class=\"accordion-group block leading-1 opt-1\" content-class=\"accordion-group__panel wysiwyg-content\">\n          <template #accordion-trigger=\"{ href, visible, setRef, clickHandler }\">\n            <a :href=\"'#' + href\" \n              :ref=\"setRef\"\n              :class=\"['accordion-group__button scroll-mt-160', {'accordion__trigger_active': visible}]\"\n              @click.stop.prevent=\"clickHandler\"\n            >\n            <span class=\"block py-10\">\n              Publications\n            <\/span>\n            <span class=\"accordion-group-icon relative flex w-56 h-56 ml-20 justify-center items-center bg-black rounded-full flex-shrink-0\">\n                            <span class=\"w-16 icon-chevron-down\">\n                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><!--!Font Awesome Free 6.6.0 by @fontawesome - https:\/\/fontawesome.com License - https:\/\/fontawesome.com\/license\/free Copyright 2024 Fonticons, Inc.--><path d=\"M233.4 406.6c12.5 12.5 32.8 12.5 45.3 0l192-192c12.5-12.5 12.5-32.8 0-45.3s-32.8-12.5-45.3 0L256 338.7 86.6 169.4c-12.5-12.5-32.8-12.5-45.3 0s-12.5 32.8 0 45.3l192 192z\"\/><\/svg>\n              <\/span>\n              <span class=\"w-16 icon-chevron-up\">\n                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><!--!Font Awesome Free 6.6.0 by @fontawesome - https:\/\/fontawesome.com License - https:\/\/fontawesome.com\/license\/free Copyright 2024 Fonticons, Inc.--><path d=\"M233.4 105.4c12.5-12.5 32.8-12.5 45.3 0l192 192c12.5 12.5 12.5 32.8 0 45.3s-32.8 12.5-45.3 0L256 173.3 86.6 342.6c-12.5 12.5-32.8 12.5-45.3 0s-12.5-32.8 0-45.3l192-192z\"\/><\/svg>\n              <\/span>\n                          <\/span>\n            <\/a>\n          <\/template>\n          <template #accordion-content>\n            <p>See a complete PubMed list of publications by <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=miklos+peterfy\" target=\"_blank\" rel=\"noopener noreferrer\">Miklos Peterfy, PhD.<\/a><\/p>\n<p><strong>Selected Key Publications<\/strong><\/p>\n<p>Ehrhardt, N., Cui, J., Dagdeviren, S., Saengnipanthkul, S., Goodridge, H. S., Kim, J. K., Lantier, L., Guo, X., Chen, Y. I., Raffel, L. J., Buchanan, T. A., Hsueh, W. A., Rotter, J. I., Goodarzi, M. O., <strong>Peterfy, M.<\/strong> (2019) Adiposity-Independent Effects of Aging on Insulin Sensitivity and Clearance in Mice and Humans. <em>Obesity<\/em> 27:434-443. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30801985\">Link to publication<\/a><\/p>\n<p><strong>Peterfy, M.<\/strong>, Bedoya, C., Giacobbe, C., Pagano, C., Gentile, M., Rubba, P., Fortunato, G., Di Taranto, M. D. (2018) Characterization of two novel pathogenic variants at compound heterozygous status in Lipase Maturation Factor 1 (LMF1) gene causing severe hypertriglyceridemia. <em>J. Clin. Lipidol<\/em>. 12: 1253-1259. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30172716\">Link to publication<\/a><\/p>\n<p>Ehrhardt, N., Doche, M. E., Chen, S., Mao, H. Z., Walsh, M. T., Bedoya, C., Guindi, M., Xiong, W., Irudayam, J. I., Iqbal, J., Fuchs, S., French, S. W., Hussain, M. M., Arditi, M., Arumugaswami, V., <strong>Peterfy, M<\/strong>. (2017) Hepatic Tm6sf2 overexpression affects cellular ApoB-trafficking, plasma lipid levels, hepatic steatosis and atherosclerosis. <em>Hum. Mol. Gen<\/em>. 26: 2719-2731. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28449094\">Link to publication<\/a><\/p>\n<p>Labadzhyan, A., Cui, J., <strong>Peterfy, M.<\/strong>, Guo, X., Chen, Y.I., Hsueh, W.A., Rotter, J.I., Goodarzi, M.O. (2016) Insulin clearance is sssociated with hepatic lipase activity and lipid and adiposity traits in Mexican Americans. <em>PLOS One<\/em> 11: e0166263. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27846285\">Link to publication<\/a><\/p>\n<p>Sha H, Sun S, Francisco AB, Ehrhardt N, Xue Z, Liu L, Lawrence P, Mattijssen F, Guber RD, Panhwar MS, Brenna JT, Shi H, Xue B, , Kersten S, Bensadoun A, <strong>Peterfy M*<\/strong>, Long Q*, Qi L.* The ER-associated degradation adapter protein Sel1L regulates LPL secretion and lipid metabolism. <em>Cell Metab<\/em>. 2014;20(3):458-470. *co-senior authors. <a href=\"https:\/\/www.cell.com\/cell-metabolism\/fulltext\/S1550-4131(14)00307-6\" target=\"_blank\" rel=\"noopener\">Link to publication<\/a><\/p>\n<p>Mao HZ, Ehrhardt N, Bedoya C, Gomez JA, DeZwaan-McCabe D, Mungrue IN, Kaufman RJ, Rutkowski DT, <strong>Peterfy M<\/strong>. Lipase maturation factor 1 (lmf1) is induced by endoplasmic reticulum stress through activating transcription factor 6\u03b1 (Atf6\u03b1) signaling. <em>J Biol Chem<\/em>. 2014;289(35):24417-24427. <a href=\"https:\/\/www.jbc.org\/content\/289\/35\/24417\">.Link to publication<\/a><\/p>\n<p>Ehrhardt N, Bedoya C, <strong>Peterfy M<\/strong>. Embryonic viability, lipase deficiency, hypertriglyceridemia and neonatal lethality in a novel LMF1-deficient mouse model.<em> Nutr Metab<\/em>. 2014;11:37-45. <a href=\"https:\/\/www.nutritionandmetabolism.com\/content\/11\/1\/37\">Link to publication<\/a><\/p>\n<p>Hosseini M, Ehrhardt N, Weissglas-Volkov D, Lai CM, Mao HZ, Liao JL, Nikkola E, Bensadoun A, Taskinen MR, Doolittle MH, Pajukanta P, <strong>Peterfy M<\/strong>. Transgenic expression and genetic variation of Lmf1 affect LPL activity in mice and humans. <em>Arterioscler Thromb Vasc Biol<\/em>. 2012;32(5):1204-1210. <a href=\"https:\/\/atvb.ahajournals.org\/content\/32\/5\/1204.\">Link to publication<\/a><\/p>\n<p><strong>Peterfy M<\/strong>. Lipase maturation factor 1: a lipase chaperone involved in lipid metabolism. Biochim Biophys Acta. 2012;1821(5):790-794. <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1388198111002083\">Link to publication<\/a><\/p>\n<p>Doolittle MH, Ehrhardt N, <strong>Peterfy M<\/strong>. Lipase maturation factor 1: structure and role in lipase folding and assembly. <em>Curr Opin Lipidol<\/em>. 2010;21(3):198-203.<a href=\"https:\/\/journals.lww.com\/co-lipidology\/Abstract\/2010\/06000\/Lipase_maturation_factor_1__structure_and_role_in.7.aspx\">Link to publication<\/a><\/p>\n<p>Davis RC, Castellani LW, Hosseini M, Ben-Zeev O, Mao HZ, Weinstein MM, Jung DY, Jun JY, Kim JK, Lusis AJ, <strong>Peterfy M<\/strong>. Early hepatic insulin resistance precedes the onset of diabetes in obese C57BLKS-db\/db mice.<em> Diabetes<\/em>. 2010;59(7):1616-1625. <a href=\"https:\/\/diabetes.diabetesjournals.org\/content\/59\/7\/1616\">Link to publication<\/a><\/p>\n<p>Cefalu AB, Noto D, Arpi ML, Yin F, Spina R, Hilden H, Barbagallo CM, Carroccio A, Tarugi P, Squatrito S, Vigneri R, Taskinen M-R, <strong>Peterfy M<\/strong>, Averna MR. Novel LMF1 nonsense mutation in a patient with severe hypertriglyceridemia. <em>J Clin Endocrin Metab<\/em>. 2009;94(11):4584-4590. <a href=\"https:\/\/press.endocrine.org\/doi\/abs\/10.1210\/jc.2009-0594\">Link to publication<\/a><\/p>\n<p>Yin F, Doolittle MH, <strong>Peterfy M<\/strong>. A quantitative assay measuring the function of lipase maturation factor 1. <em>J Lipid Res<\/em>. 2009;50(11):2265-2269. <a href=\"https:\/\/www.jlr.org\/content\/50\/11\/2265\">Link to publication<\/a><\/p>\n<p><strong>Peterfy M<\/strong>, Ben-Zeev O, Mao HZ, Weissglas-Volkov D, Aouizerat BE, Pullinger CR, Frost PH, Kane JP, Malloy MJ, Reue K, Pajukanta P, Doolittle MH. Mutations in LMF1 cause combined lipase deficiency and severe hypertriglyceridemia. <em>Nat Genet<\/em>. 2007;39(12):1483-1487. <a href=\"https:\/\/www.nature.com\/ng\/journal\/v39\/n12\/full\/ng.2007.24.html\">Link to publication<\/a><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n\n          <\/template>\n        <\/app-accordion-item>\n              <app-accordion-item class=\"accordion-group block leading-1 opt-1\" content-class=\"accordion-group__panel wysiwyg-content\">\n          <template #accordion-trigger=\"{ href, visible, setRef, clickHandler }\">\n            <a :href=\"'#' + href\" \n              :ref=\"setRef\"\n              :class=\"['accordion-group__button scroll-mt-160', {'accordion__trigger_active': visible}]\"\n              @click.stop.prevent=\"clickHandler\"\n            >\n            <span class=\"block py-10\">\n              Lab Members\n            <\/span>\n            <span class=\"accordion-group-icon relative flex w-56 h-56 ml-20 justify-center items-center bg-black rounded-full flex-shrink-0\">\n                            <span class=\"w-16 icon-chevron-down\">\n                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><!--!Font Awesome Free 6.6.0 by @fontawesome - https:\/\/fontawesome.com License - https:\/\/fontawesome.com\/license\/free Copyright 2024 Fonticons, Inc.--><path d=\"M233.4 406.6c12.5 12.5 32.8 12.5 45.3 0l192-192c12.5-12.5 12.5-32.8 0-45.3s-32.8-12.5-45.3 0L256 338.7 86.6 169.4c-12.5-12.5-32.8-12.5-45.3 0s-12.5 32.8 0 45.3l192 192z\"\/><\/svg>\n              <\/span>\n              <span class=\"w-16 icon-chevron-up\">\n                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><!--!Font Awesome Free 6.6.0 by @fontawesome - https:\/\/fontawesome.com License - https:\/\/fontawesome.com\/license\/free Copyright 2024 Fonticons, Inc.--><path d=\"M233.4 105.4c12.5-12.5 32.8-12.5 45.3 0l192 192c12.5 12.5 12.5 32.8 0 45.3s-32.8 12.5-45.3 0L256 173.3 86.6 342.6c-12.5 12.5-32.8 12.5-45.3 0s-12.5-32.8 0-45.3l192-192z\"\/><\/svg>\n              <\/span>\n                          <\/span>\n            <\/a>\n          <\/template>\n          <template #accordion-content>\n            <div class=\"sm:flex w-full py-32 border-b-1 border-gray\">\n        <a href=\"\" class=\"card block w-256 sm:w-1\/3 pl-12 md:pl-0 pr-12 md:pr-18 mr-auto md:mr-0\"><\/p>\n<div class=\"rounded-5 md:rounded-8 overflow-hidden\">\n            <img decoding=\"async\" class=\"card__image w-full h-256 sm:h-192 md:h-144 lg:h-192 xl:h-256 object-cover\" alt=\"WesternU Seal - Default Image\" src=\"\/media\/westernu\/images\/facstaffnopic.jpg\" \/>\n        <\/div>\n<p>    <\/a><\/p>\n<div class=\"w-full h-full md:w-2\/3 pl-12 md:pl-18 mt-18 sm:mt-0\">\n<p class=\"t-h2-serif leading-120\">\n            <a href=\"\" class=\"text-red-light hover:text-red\">Nicole Ehrhardt, PhD<\/a>\n        <\/p>\n<div class=\"mt-16 t-p2\">\n<p class=\"font-bold\">Research Assistant Professor<\/p>\n<p>\n                <a href=\"mailto:nehrhardt@westernu.edu\" class=\"hover:underline\">nehrhardt@westernu.edu <\/a>\n            <\/p>\n<\/p><\/div>\n<\/p><\/div>\n<\/div>\n<div class=\"sm:flex w-full py-32 border-b-1 border-gray\">\n        <a href=\"\" class=\"card block w-256 sm:w-1\/3 pl-12 md:pl-0 pr-12 md:pr-18 mr-auto md:mr-0\"><\/p>\n<div class=\"rounded-5 md:rounded-8 overflow-hidden\">\n            <img decoding=\"async\" class=\"card__image w-full h-256 sm:h-192 md:h-144 lg:h-192 xl:h-256 object-cover\" alt=\"Portrait of Candy Bedoya, PhD\" src=\"\/media\/westernu\/images\/staff\/cbedoya.jpg\" \/>\n        <\/div>\n<p>    <\/a><\/p>\n<div class=\"w-full h-full md:w-2\/3 pl-12 md:pl-18 mt-18 sm:mt-0\">\n<p class=\"t-h2-serif leading-120\">\n            <a href=\"\" class=\"text-red-light hover:text-red\">Candy Bedoya, PhD<\/a>\n        <\/p>\n<div class=\"mt-16 t-p2\">\n<p class=\"font-bold\">Postdoctoral Fellow<\/p>\n<p>\n                <a href=\"mailto:cbedoya@westernu.edu\" class=\"hover:underline\">cbedoya@westernu.edu <\/a>\n            <\/p>\n<\/p><\/div>\n<\/p><\/div>\n<\/div>\n<div class=\"sm:flex w-full py-32 border-b-1 border-gray\">\n        <a href=\"\" class=\"card block w-256 sm:w-1\/3 pl-12 md:pl-0 pr-12 md:pr-18 mr-auto md:mr-0\"><\/p>\n<div class=\"rounded-5 md:rounded-8 overflow-hidden\">\n            <img decoding=\"async\" class=\"card__image w-full h-256 sm:h-192 md:h-144 lg:h-192 xl:h-256 object-cover\" alt=\"WesternU Seal - Default Image\" src=\"\/media\/westernu\/images\/facstaffnopic.jpg\" \/>\n        <\/div>\n<p>    <\/a><\/p>\n<div class=\"w-full h-full md:w-2\/3 pl-12 md:pl-18 mt-18 sm:mt-0\">\n<p class=\"t-h2-serif leading-120\">\n            <a href=\"\" class=\"text-red-light hover:text-red\">David Stufflebeam<\/a>\n        <\/p>\n<div class=\"mt-16 t-p2\">\n<p class=\"font-bold\">MS Student in Biomedical Sciences<\/p>\n<p>\n                <a href=\"mailto:david.stufflebeam@westernu.edu\" class=\"hover:underline\">david.stufflebeam@westernu.edu <\/a>\n            <\/p>\n<\/p><\/div>\n<\/p><\/div>\n<\/div>\n<p><strong>\u00a0<\/strong><\/p>\n\n          <\/template>\n        <\/app-accordion-item>\n          <\/app-accordion>\n  <\/div>\n<\/section>\n\n<section class=\"faculty-card my-48 md:my-72\">\n  <div class=\"container\">\n        <div class=\"md:flex md:justify-between md:items-end mb-20\">\n      <h2 class=\"t-h2-sans  text-red md:mr-40\">MIKLOS PETERFY, PhD<\/h2>\n    <\/div>\n            <div class=\"md:flex md:flex-wrap px-12\">\n                                                      \n                                                        \n      <div class=\"px-12 mt-24 w-full md:w-1\/2\">\n        <div class=\"sm:flex w-full py-32 border-b-1 border-gray\">\n                                            <a href=\"\/bios\/?bio=mpeterfy\" class=\"card block w-256 sm:w-1\/3 pl-12 md:pl-0 pr-12 md:pr-18 mr-auto md:mr-0\">\n                <div class=\"rounded-5 md:rounded-8 overflow-hidden\">\n                    <img decoding=\"async\" class=\"card__image w-full h-256 sm:h-192 md:h-144 lg:h-192 xl:h-256 object-cover\" alt=\"Portrait of MIKLOS PETERFY, PhD\" src=\"\/media\/westernu\/images\/staff\/mpeterfy.jpg\" \/>\n                <\/div>\n            <\/a>\n                                <div class=\"w-full h-full md:w-2\/3 pl-12 md:pl-18 mt-18 sm:mt-0\">\n            <p class=\"t-h2-serif leading-120\">\n                            <a href=\"\/bios\/?bio=mpeterfy\" class=\"text-red-light hover:text-red\">MIKLOS PETERFY, PhD<\/a>\n                          <\/p>\n            <div class=\"mt-16 t-p2\">\n                            <p class=\"font-bold\">College of Osteopathic Medicine of the Pacific<\/p>\n                                          <p class=\"font-bold\">Professor of Biochemistry<\/p>\n                                          <p>\n                <a href=\"tel:3949\" class=\"hover:underline\">3949<\/a>\n              <\/p>\n                                                        <p>\n                <a href=\"mailto:mpeterfy@westernu.edu\" class=\"hover:underline\">mpeterfy@westernu.edu <\/a>\n              <\/p>\n                                        <\/div>\n          <\/div>\n        <\/div>\n      <\/div>\n          <\/div>\n      <\/div>\n<\/section>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":34,"featured_media":0,"parent":8215,"menu_order":8,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-2956","page","type-page","status-publish","hentry"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/stagewp.westernu.edu\/osteopathic\/wp-json\/wp\/v2\/pages\/2956","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/stagewp.westernu.edu\/osteopathic\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/stagewp.westernu.edu\/osteopathic\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/stagewp.westernu.edu\/osteopathic\/wp-json\/wp\/v2\/users\/34"}],"replies":[{"embeddable":true,"href":"https:\/\/stagewp.westernu.edu\/osteopathic\/wp-json\/wp\/v2\/comments?post=2956"}],"version-history":[{"count":14,"href":"https:\/\/stagewp.westernu.edu\/osteopathic\/wp-json\/wp\/v2\/pages\/2956\/revisions"}],"predecessor-version":[{"id":14843,"href":"https:\/\/stagewp.westernu.edu\/osteopathic\/wp-json\/wp\/v2\/pages\/2956\/revisions\/14843"}],"up":[{"embeddable":true,"href":"https:\/\/stagewp.westernu.edu\/osteopathic\/wp-json\/wp\/v2\/pages\/8215"}],"wp:attachment":[{"href":"https:\/\/stagewp.westernu.edu\/osteopathic\/wp-json\/wp\/v2\/media?parent=2956"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}